/* * nvbio * Copyright (c) 2011-2014, NVIDIA CORPORATION. All rights reserved. * * Redistribution and use in source and binary forms, with or without * modification, are permitted provided that the following conditions are met: * * Redistributions of source code must retain the above copyright * notice, this list of conditions and the following disclaimer. * * Redistributions in binary form must reproduce the above copyright * notice, this list of conditions and the following disclaimer in the * documentation and/or other materials provided with the distribution. * * Neither the name of the NVIDIA CORPORATION nor the * names of its contributors may be used to endorse or promote products * derived from this software without specific prior written permission. * * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE * DISCLAIMED. IN NO EVENT SHALL NVIDIA CORPORATION BE LIABLE FOR ANY * DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS * SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. */ #pragma once #include #include #include #include "haplotype_caller.h" #include "assembly_types.h" using namespace nvbio; void local_assembly(assembly_pipeline* pipeline) { // [read correction] // create assembly graphs for given kmer size(s) debruijn_graph assembly_graph; assembly_graph.construct_graph( pipeline->d_seq_set, pipeline->d_active_region_ids, pipeline->kmer_size, false); printf("Constructed assembly graph for kmer size %u with %u nodes and %u edges \n", pipeline->kmer_size, assembly_graph.n_nodes, assembly_graph.n_edges); //assembly_graph.print_dot_graph(pipeline->d_seq_set); // check complexity // assembly_graph.topological_sort(); // check for cycles // post-process: pruning, dangling chain recovery... // find best paths //assembly_graph.find_k_best_paths(pipeline->k_best_haplotypes); }