/* * nvbio * Copyright (c) 2011-2014, NVIDIA CORPORATION. All rights reserved. * * Redistribution and use in source and binary forms, with or without * modification, are permitted provided that the following conditions are met: * * Redistributions of source code must retain the above copyright * notice, this list of conditions and the following disclaimer. * * Redistributions in binary form must reproduce the above copyright * notice, this list of conditions and the following disclaimer in the * documentation and/or other materials provided with the distribution. * * Neither the name of the NVIDIA CORPORATION nor the * names of its contributors may be used to endorse or promote products * derived from this software without specific prior written permission. * * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE * DISCLAIMED. IN NO EVENT SHALL NVIDIA CORPORATION BE LIABLE FOR ANY * DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS * SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. */ #pragma once #include #include namespace nvbio { namespace alndiff { enum Type { LOWER = 0, HIGHER = 1 }; enum Bins { LINEAR = 0, LOG = 1 }; struct StatsPartition { Histogram<256> hist; Histogram2d<12,10> hist_by_length; Histogram2d<12,10> hist_by_mapQ; Histogram<256> diff_hist; Histogram2d<12,10> diff_hist_by_length; Histogram2d<32,10> diff_hist_by_value_neg; Histogram2d<32,10> diff_hist_by_value_pos; Histogram2d<7,12> diff_hist_by_mapQ1; Histogram2d<7,12> diff_hist_by_mapQ2; }; template struct Stats { static const Type TYPE = TYPE_T; static const Bins BINS = BINS_T; typedef StatsPartition Partition; Bins bin_type() const { return BINS; } int32 push(const int32 val1, const int32 val2, const uint32 length_bin, const uint32 mapQ1, const uint32 mapQ2) { l.hist.push( (BINS == LOG) ? log_bin(val1) : val1 ); l.hist_by_length.push( length_bin, log_bin( val1 ) ); l.hist_by_mapQ.push( log_bin( mapQ1 ), log_bin( val1 ) ); r.hist.push( (BINS == LOG) ? log_bin(val2) : val2 ); r.hist_by_length.push( length_bin, log_bin( val2 ) ); r.hist_by_mapQ.push( log_bin( mapQ2 ), log_bin( val2) ); if (TYPE == LOWER) { const int32 diff = int32(val2) - int32(val1); if (diff >= 0) { const int32 log_diff = log_bin( diff ); l.diff_hist.push( (BINS == LOG) ? log_diff : diff ); l.diff_hist_by_length.push( length_bin, log_diff ); l.diff_hist_by_mapQ1.push( log_bin(mapQ1), log_diff ); l.diff_hist_by_mapQ2.push( log_bin(mapQ2), log_diff ); if (val1 < 0) l.diff_hist_by_value_neg.push( log_bin(-val1), log_diff ); else l.diff_hist_by_value_pos.push( log_bin(val1), log_diff ); } if (diff <= 0) { const int32 log_diff = log_bin( -diff ); r.diff_hist.push( (BINS == LOG) ? log_diff : -diff ); r.diff_hist_by_length.push( length_bin, log_diff ); r.diff_hist_by_mapQ1.push( log_bin(mapQ1), log_diff ); r.diff_hist_by_mapQ2.push( log_bin(mapQ2), log_diff ); if (val2 < 0) r.diff_hist_by_value_neg.push( log_bin(-val2), log_diff ); else r.diff_hist_by_value_pos.push( log_bin(val2), log_diff ); } return diff; } else { const int32 diff = int32(val1) - int32(val2); if (diff >= 0) { const int32 log_diff = log_bin( diff ); l.diff_hist.push( (BINS == LOG) ? log_diff : diff ); l.diff_hist_by_length.push( length_bin, log_diff ); l.diff_hist_by_mapQ1.push( log_bin(mapQ1), log_diff ); l.diff_hist_by_mapQ2.push( log_bin(mapQ2), log_diff ); if (val2 < 0) l.diff_hist_by_value_neg.push( log_bin(-val2), log_diff ); else l.diff_hist_by_value_pos.push( log_bin(val2), log_diff ); } if (diff <= 0) { const int32 log_diff = log_bin( -diff ); r.diff_hist.push( (BINS == LOG) ? log_diff : -diff ); r.diff_hist_by_length.push( length_bin, log_diff ); r.diff_hist_by_mapQ1.push( log_bin(mapQ1), log_diff ); r.diff_hist_by_mapQ2.push( log_bin(mapQ2), log_diff ); if (val1 < 0) r.diff_hist_by_value_neg.push( log_bin(-val1), log_diff ); else r.diff_hist_by_value_pos.push( log_bin(val1), log_diff ); } return diff; } } Partition l; Partition r; }; struct AlignmentStats { Stats higher_score; Stats lower_ed; Stats higher_mapQ; Stats longer_mapping; Stats higher_pos; Stats lower_subs; Stats lower_ins; Stats lower_dels; Stats lower_mms; }; } // namespace alndiff } // namespace nvbio