123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100101102103104105106107108109110111112113114115116117118119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172 |
- /*
- * nvbio
- * Copyright (c) 2011-2014, NVIDIA CORPORATION. All rights reserved.
- *
- * Redistribution and use in source and binary forms, with or without
- * modification, are permitted provided that the following conditions are met:
- * * Redistributions of source code must retain the above copyright
- * notice, this list of conditions and the following disclaimer.
- * * Redistributions in binary form must reproduce the above copyright
- * notice, this list of conditions and the following disclaimer in the
- * documentation and/or other materials provided with the distribution.
- * * Neither the name of the NVIDIA CORPORATION nor the
- * names of its contributors may be used to endorse or promote products
- * derived from this software without specific prior written permission.
- *
- * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND
- * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED
- * WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
- * DISCLAIMED. IN NO EVENT SHALL NVIDIA CORPORATION BE LIABLE FOR ANY
- * DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES
- * (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES;
- * LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND
- * ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT
- * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS
- * SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
- */
- ///
- ///\file reduce.h
- ///
- #pragma once
- #include <nvBowtie/bowtie2/cuda/defs.h>
- #include <nvBowtie/bowtie2/cuda/scoring.h>
- #include <nvBowtie/bowtie2/cuda/params.h>
- namespace nvbio {
- namespace bowtie2 {
- namespace cuda {
- struct ParamsPOD;
- template <typename ScoringScheme> struct BaseScoringPipelineState;
- template <typename ScoringScheme> struct BestApproxScoringPipelineState;
- ///@addtogroup nvBowtie
- ///@{
- ///@addtogroup Reduce
- ///@{
- ///
- /// A context class for the score_reduce_kernel to be used in best-approx pipeline.
- ///
- /// \details
- /// Implements the basic extension bail-out mechanisms of Bowtie2, namely stopping
- /// when a given number of extensions of a read failed in a row.
- /// This is done keeping a vector of per-read extension 'trys' counters, which
- /// start from the maximum allowed number, and get decremented towards zero upon
- /// each failure, or reset upon successful extensions.
- ///
- struct ReduceBestApproxContext
- {
- /// constructor
- ///
- /// \param trys trys vector
- /// \param n_ext total number of extensions (i.e. extension loops) already performed
- ///
- ReduceBestApproxContext(uint32* trys, const uint32 n_ext) : m_trys( trys ), m_ext( n_ext ) {}
- /// this method is called from score_reduce_kernel to report updates to the best score.
- ///
- NVBIO_FORCEINLINE NVBIO_DEVICE
- void best_score(const uint32 read_id, const ParamsPOD& params) const
- {
- // reset the try counter
- m_trys[ read_id ] = params.max_effort;
- }
- /// this method is called from score_reduce_kernel to report updates to the second best score.
- ///
- NVBIO_FORCEINLINE NVBIO_DEVICE
- void second_score(const uint32 read_id, const ParamsPOD& params) const
- {
- // reset the try counter
- m_trys[ read_id ] = params.max_effort;
- }
- /// this method is called from score_reduce_kernel to report extension failures.
- ///
- NVBIO_FORCEINLINE NVBIO_DEVICE
- bool failure(const uint32 idx, const uint32 read_id, const uint32 top_flag, const ParamsPOD& params) const
- {
- if (m_trys[ read_id ] > 0)
- {
- if (((m_ext+idx >= params.min_ext) && (top_flag == 0) && (--m_trys[ read_id ] == 0)) || // bowtie2 does 1 more alignment than effort limit, we don't
- (m_ext+idx >= params.max_ext))
- return true;
- }
- return false;
- }
- private:
- uint32* m_trys;
- uint32 m_ext;
- };
- ///
- /// A context class for the score_reduce_kernel to be used in best-exact pipeline.
- ///
- /// \details
- /// A trivial implementation, that never bails out.
- ///
- struct ReduceBestExactContext
- {
- ReduceBestExactContext() {}
- /// this method is called from score_reduce_kernel to report updates to the best score.
- ///
- NVBIO_FORCEINLINE NVBIO_DEVICE
- void best_score(const uint32 read_id, const ParamsPOD& params) const {}
- /// this method is called from score_reduce_kernel to report updates to the second best score.
- ///
- NVBIO_FORCEINLINE NVBIO_DEVICE
- void second_score(const uint32 read_id, const ParamsPOD& params) const {}
- /// this method is called from score_reduce_kernel to report extension failures.
- ///
- NVBIO_FORCEINLINE NVBIO_DEVICE
- bool failure(const uint32 idx, const uint32 read_id, const uint32 top_flag, const ParamsPOD& params) const { return false; }
- };
- ///
- /// Reduce the scores associated to each read in the scoring queue to find the best 2 alignments.
- ///
- void score_reduce(
- const ReduceBestApproxContext context,
- const BestApproxScoringPipelineState<EditDistanceScoringScheme>& pipeline,
- const ParamsPOD& params);
- ///
- /// Reduce the scores associated to each read in the scoring queue to find the best 2 alignments.
- ///
- void score_reduce(
- const ReduceBestApproxContext context,
- const BestApproxScoringPipelineState<SmithWatermanScoringScheme<> >& pipeline,
- const ParamsPOD& params);
- ///
- /// Reduce the scores associated to each paired-end read in the scoring queue to find the best 2 alignments.
- ///
- void score_reduce_paired(
- const ReduceBestApproxContext context,
- const BestApproxScoringPipelineState<EditDistanceScoringScheme>& pipeline,
- const ParamsPOD& params);
- ///
- /// Reduce the scores associated to each paired-end read in the scoring queue to find the best 2 alignments.
- ///
- void score_reduce_paired(
- const ReduceBestApproxContext context,
- const BestApproxScoringPipelineState<SmithWatermanScoringScheme<> >& pipeline,
- const ParamsPOD& params);
- ///@} // group Reduce
- ///@} // group nvBowtie
- } // namespace cuda
- } // namespace bowtie2
- } // namespace nvbio
- #include <nvBowtie/bowtie2/cuda/reduce_inl.h>
|